Tag Archive for Diarrhoea

Fake Feces To Treat Deadly Disease: Scientists Find They Can Just Make Shit Up

By Christie Wilcox | January 10, 2013 |

With more and more strains of C. difficile becoming resistant to antibiotics, doctors have had to find creative ways to treat the infection. One of the most promising (if not revolting) treatments that has been tested in recent years is called fecal bacteriotherapy or ‘stool transplant’, which involves taking donor poop from a healthy patient and inserting it into the gut of an infected one as a form of probiotics, seeking to replace the protective flora.

Read more on the Scientific American blog about RePOOPupulating.

 

Predictors of parasitic and bacterial causes of diarrhoea in travellers.

Trans R Soc Trop Med Hyg. 2012 Sep;106(9):549-53. doi: 10.1016/j.trstmh.2012.04.008. Epub 2012 Jul 20.
Geographic, symptomatic and laboratory predictors of parasitic and bacterial causes of diarrhoea in travellers.
McGregor AC, Whitty CJ, Wright SG.

Hospital for Tropical Diseases, Capper Street, London WC1E 6AU, UK. alastairmcgregor@yahoo.co.uk
Abstract

An observational study of patients presenting with diarrhoea to a walk-in service for returning travellers was conducted with the aim of identifying features that would help predict whether pathogens were bacterial or parasitic. In total, 509 cases were included, of which a bacterial aetiology was found in 55/440 (12.5%) and a parasitic cause in 51/428 (11.9%). Patients with symptoms of ≤14 days were significantly more likely to have a bacterial diagnosis than those with longer symptoms (p<0.001), whereas parasitic causes of diarrhoea were not associated with length of symptoms and became proportionately more likely with time. Raised CRP, faecal white cells and fever were all predictive of positive bacterial culture (p<0.001, p=0.001 and p=0.001, respectively) but did not predict parasitic infection. Travellers to South and Southeast Asia were more likely to have parasites detected in their stool than travellers to other tropical areas (OR=1.96; p=0.041). Gender, ethnicity, reason for travel and length of stay abroad were not significantly associated with the faecal pathogen identified.
gotworms2

Note from Robert ten Hove

The study on bacterial and parasitic infections among returning travelers was well performed. Interesting to see such a difference in travelers destinations. The majority of patients at the British clinic returned from India / South-East Asia whereas in The Netherlands and Belgium the majority of travelers return from the African continent. Nonetheless, nothing remarkable about percentages. It was good to read that Dientamoeba fragilis is not considered as a pathogen.

The most important message of this article is the one that is not mentioned. The writers do suggest that the absence of a good gold standard makes estimating the sensitivity of a stool microscopy difficult… In several countries (at least in The Netherlands and Belgium), Molecular diagnostics is now considered to be the gold standard, both for the detection of parasites as for several bacteria species. Why still dabbling through the poo with culture, ELISAs, Ridley’s, Ziehl-Neelson staining, fluorescend microscopy, and so on? When you got molecular diagnostics!